Phospholipid for Liposome
Formulation

PEG-Phospholipids of the carbamate-bound type are resistant to hydrolysis, and are therefore being used for the commercial production of PEGylated liposomes. As NOF employs its own high-quality Activated PEGs and phospholipids, high-quality PEG-Phospholipids can be supplied. As listed below, NOF can provide new types of phospholipid derivatives bound to polyglycerine and multi-arm PEGs as hydrophilic polymers.
Because of the direct binding of the PEG chains to diacylglycerol, this product series is devoid of phosphorylethanolamine groups and other binding sites. Accordingly, they are resistant to hydrolysis and are suitable for application to drugs that are vulnerable to ionic charges.
Concerning this product, NOF has officially registered its product patent in Japan.
In addition to methoxypolyethyleneglycol, NOF provides various kinds of high-purity monoalkyl-substituted polyethyleneglycols. When hydrocarbon moieties comprising more than 8 carbons in the alkyl groups are used, several unique surface-active effects can be obtained. These derivatives can be employed not only for surface modification of liposomes, but also for PEGylation of proteins by the introduction of various functional groups to the PEG chain terminals. Evidence has also been demonstrated of the usefulness of these products as solubilizers.

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