Phospholipid for Liposome
Formulation
PEGylated Lipids
PEGylated Lipids can be applied to liposomal drug formulations to prolong the plasma half-life of the drugs. Coating of the liposomal surface with polyethylene glycol would suppress the uptake of the drug by the reticuloendothelial system, thereby prolonging the half-life of the drug in the plasma.
PEG-modified lipids can also be used as emulsifiers and stabilizers of microspheres in aqueous solutions.
PEG-modified lipids can also be used as emulsifiers and stabilizers of microspheres in aqueous solutions.

・PEG-Phospholipids
・New Hydrophilic Phospholipid Derivatives
・Diacylglycerol-PEG
・Cholesterol-PEG Derivatives
PEG-Phospholipids of the carbamate-bound type are resistant to hydrolysis, and are therefore being used for the commercial production of PEGylated liposomes. As NOF employs its own high-quality Activated PEGs and phospholipids, high-quality PEG-Phospholipids can be supplied.
・New Hydrophilic Phospholipid Derivatives
・Diacylglycerol-PEG
・Cholesterol-PEG Derivatives
Concerning this product, NOF has officially registered its product patent in Japan.

Serum clearance efficiency of new PEG-Lipid derivatives in Liposomes




