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Liposome technical information
4. Transferrin attached liposome
Transferrin (Tf) is an iron-binding glycoprotein made up of single chain peptide, and its molecular weight is 80,000. It is found in blood in the concentration of 246 - 444mg/dL, and involved in iron supply via Tf receptors on the surface of the cells. Together with increased angiogenesis overexpression of Tf receptors is also observed in various tumor cells. The receptor is recycled after uptake of Tf into the cell, and there is no fusion with lysosome after internalization. Therefore, Tf as the target ligand for tumor tissues may be very useful.
Iinuma et al. studied liposomal uptake to tumor cells with time course using MKN45P, human stomach cancer cells.Liposome with Tf conjugated to an end of PEG-attached phospholipid is significantly easier to be taken in the cell than PEG liposome without Tf. Iinuma et al.further studied Cisplatin delivery to the tumor cells by preparing liposome containing Cisplatin and injecting it into the abdomen of mice bearing MKN45P tumor cells, and reported survival study. The more uptake by the tumor cells, the better survival rate. Therefore Tf-modified liposome is confirmed to be superior to normal liposome and PEG-liposome.
Iinuma et al. studied liposomal uptake to tumor cells with time course using MKN45P, human stomach cancer cells.Liposome with Tf conjugated to an end of PEG-attached phospholipid is significantly easier to be taken in the cell than PEG liposome without Tf. Iinuma et al.further studied Cisplatin delivery to the tumor cells by preparing liposome containing Cisplatin and injecting it into the abdomen of mice bearing MKN45P tumor cells, and reported survival study. The more uptake by the tumor cells, the better survival rate. Therefore Tf-modified liposome is confirmed to be superior to normal liposome and PEG-liposome.
   
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