Phospholipid for Liposome
Formulation

Recent progress in molecular biology and molecular embryology makes identification of various antigens appearing on tumor cells possible. Antigens that specifically appear on tumor cells include ganglioside GM3 on melanoma, MUC1, MUC2, and MUC3 on the surfaces of breast cancer, lung cancer and prostate cancer, and Lewis X on the surface of digestive cancer. Antigens preferentially overexpressed on tumor cells are also reported, and those include transferrin receptor, folic acid receptor, CD19, and CD20. Preparation of antibodies or ligands for these tumor-associated antigens and binding them to PEG end of PEG liposome may be effective for anti-cancer drugs to be delivered to tumor cells. Nam et al. made immunoliposome using antibodies for Lewis X and ganglioside GM3 and studied the drug delivery. Maruyama et al. also reported the targeting effect using transferrin modified liposome and anti-CD antibody modified liposome.